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La maladie entre boeufs. La consommation d'aliments pour animaux contenant des tissus infectieux a t identifie comme tant la principale voie de transmission. Parmi les espces ayant contract une forme de la maladie par consommation de tissus infects par l'agent de l'ESB, signalons les boeufs, les caprins, les humains, les flins ainsi que les primates et les onguls gards en captivit dans les jardins zoologiques. Il est possible que, dans certains pays, avant qu'on interdise les protines de ruminants dans les aliments pour animaux, des moutons, des buffles d'Asie, des bisons, des cervids et des camlids aient t nourris avec des farines de viande et d'os contamines par l'agent de l'ESB, mais, actuellement, il n'existe aucune donne permettant de conclure que l'ESB est prsente chez l'une ou l'autre de ces espces dans les conditions d'levage classique. Des tudes ont rvl que, chez les boeufs, l'infectiosit la plus leve est limite aux tissus du systme nerveux central des animaux prsentant les signes cliniques de la maladie, y compris le cerveau, la moelle pinire et la rtine, l'infectiosit se manifestant au dbut dans les tissus du systme lymphorticulaire, pour ensuite apparatre dans le systme nerveux priphrique puis, la fin de la priode d'incubation, dans le systme nerveux central. On a observ des signes d'infectiosit dans certaines parties de la cervelle, dans la moelle pinire et les ganglions de la racine dorsale peine trois mois avant l'apparition des signes cliniques. D'autres tissus, comme ceux de l'ilon distal, peuvent tre infectieux avant que l'infectiosit soit dtectable dans le systme nerveux central. C'est pour cette raison qu'on a dcid d'enlever des carcasses de boeuf certains tissus regroups sous la dsignation MRS, au moment de l'abattage. Ces tissus seraient l'origine de plus de 99 p. 100 de l'infectiosit de l'ESB. Lien entre l'ESB et les autres EST Les EST, dont certaines, croit-on, existent depuis des sicles, incluent des variantes qui touchent les humains, dont la maladie de Creutzfeldt-Jakob, le kuru, le syndrome Gerstmann-StausslerScheinker et l'insomnie familiale fatale, ainsi que la tremblante qui touche le mouton, l'encphalopathie transmissible du vison, la maladie dbilitante chronique qui touche le cerf et le wapiti, l'encphalopathie spongiforme fline et l'encphalopathie spongiforme bovine. Ces maladies se caractrisent par une longue priode d'incubation et il n'existe contre elles ni proplylaxie ni traitement connus. Plusieurs incertitudes scientifiques demeurent au sujet de l'ESB et de l'agent qui cause cette maladie, et la collectivit scientifique y consacre beaucoup d'efforts, surtout depuis la confirmation, en 1996, de la vMCJ chez l'humain et de son lien avec l'ESB. Selon les donnes exprimentales et pidmiologiques dont on dispose maintenant, la vMCJ serait probablement cause par l'agent de l'ESB et, bien que la voie orale semble la plus probable pour la transmission aux boeufs et aux humains, beaucoup de questions subsistent sur les autres voies d'exposition possibles, la dose infectieuse, l'infectiosit relative des tissus, la prdisposition gntique, l'infectiosit cumulative et la barrire des espces. En avril 2006, 192 cas dfinitifs ou probables de vMCJ avaient t diagnostiqus dont 168 dcs ; : 161 cas au Royaume-Uni, 17 en France, 1 au Canada, 1 Hongkong, 3 en Irlande, 1 en Italie, 1 au Japon, 1 au Portugal, 1 en Espagne, 1 au Pays-Bas, 1 en Arabie saoudite, et 2 aux tats-Unis. L'ESB et les aliments pour animaux L'ajout de protines d'quarissage de bovins infects par l'agent de l'ESB dans les aliments du btail est considr comme and vioxx.

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Pharmos Corporation Notes to Consolidated Financial Statements For 2006, 2005 and 2004, the Company's recorded tax benefit differs from the benefit calculated by applying the statutory U.S. federal income tax rate due to the valuation allowances established on deferred tax assets in those periods and non-deductible charges, including the in - process research and development charge, offset by the aforementioned tax benefits from the sale of New Jersey NOLs. At December 31, 2006 and 2005, the Company's deferred tax assets are comprised of the following: 2006 $ 72, 838, 000 818, 000 Development Credit 7, 080, 000 8, 231, 000 860, 000 89, 801, 000 89, 801, 000 ; $ 3, 771, 000 615, 000 49, 362, 000 49, 362, 000 ; 2005 44, 034, 000 942, 000.
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