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Medicine alumnus and is currently professor and chairman of Psychiatry & Behavioral Sciences at the Medical University of South Carolina MUSC ; and a clinical professor of Psychiatry and Behavioral Sciences at Emory University School of Medicine. At MUSC he oversees an active psychiatry department consistently ranked among the top departments in the United States for research support. He is also executive director of the Institute of Psychiatry at MUSC, which includes a 90-bed inpatient hospital. The Institute was recently named one of the best hospitals in the nation for treatment of psychiatric disorders by U.S. News & World Report, and for the last two years has been named Hospital of the Year by the National Alliance for the Mentally Ill NAMI ; of South Carolina. "Dr. Oldham brings to Menninger a wealth of clinical expertise and experience working with complex medical and psychiatric systems, " said Ian Aitken, president and CEO of The Menninger Clinic. "His inter national reputation as a leader in psychiatric medicine and specialization in personality disorders is a tremendous asset to The Clinic and our affiliations with Baylor College of Medicine and The Methodist Hospital. We are pleased he is joining our team at this exciting time in our history." In his new role, Dr. Oldham's goals include continuing Menninger's shared vision with its partners to build a new international behavioral health campus located near the Texas Medical Center and working closely with Baylor College of Medicine to continue developing leading mental health patient care, research and education. After receiving a master's degree in neuroendocrinology from Baylor College of Medicine in 1966 and a medical degree from Baylor College of Medicine in 1967, Dr. Oldham completed his psychiatric training at Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, and his psychoanalytic training at the Columbia Psychoanalytic Center. He holds board certification in psychiatry, psychoanalysis and forensic psychiatry and is considered an expert in the area of personality disorders, about which he has written and lectured extensively.
Where Q3 is relevant and there is a need to determine the concentrations of individual hydrocarbons, pentane is used as the main extraction solvent, but re-distilled dichloromethane is used as part of the sample clean-up procedure. Samples are then analysed by high resolution capillary Gas Chromatography with a flame ionisation detector. The range of the application is 0-20 microgram litre. Reference: SCA. Determination of very low concentrations of hydrocarbons and halogenated hydrocarbons in water. 1985 HMSO. ISBN 0 11 752004 7. Other solvents that have been used to extract organic compounds from sediments and water are: CFC-113 for polyaromatic hydrocarbons 1991 ; , ethyl acetate; dichloromethane for benzo a ; pyrene, nitrophenols and nitroaniline USEPA CLP method 1990 n-hexane for organochlorine pesticides and lamotrigine.
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Dyax Corp. DYAX ; , Cambridge, Mass. Genzyme Corp. GENZ ; , Cambridge, Mass. Product: DX-88 Business: Cardiovascular Molecular target: Kallikrein Description: Yeast-derived recombinant kallikrein inhibitor protein Indication: Treat hereditary angioedema HAE ; Endpoint: NA Status: Interim Phase II data Milestone: Start Phase III 1H05 file BLA 2006 ; Interim data from an open-label, dose-ranging Phase II EDEMA2 trial based on 61 HAE attacks in 34 patients showed that DX-88 was well tolerated and could elicit rapid clinical responses. The clinical response in this trial is defined as relief of HAE symptoms within 4 hours of treatment. The median time to clinical response was 35 minutes. DX88 has Orphan Drug designation to treat HAE in the U.S. and Europe and Fast Track designation in the U.S. Data will be presented at the American Academy of Allergy Asthma and Immunology meeting in March in San Antonio. Elite Pharmaceuticals Inc. ELI ; , Northvale, N.J. Product: Naltrexone Business: Neurology Molecular target: NA Description: Naltrexone formulated with abuse resistant technology for narcotic analgesics Indication: Treat chronic pain Endpoint: Blood levels Status: NA Milestone: NA In an open-label, U.S. study in 12 subjects, food intake did not affect the performance of the formulation and no quantifiable levels of naltrexone were observed at a limit of quantification LOQ ; of 7.5 pg ml. The study was designed to evaluate the effect of food on absorption of naltrexone. Indication: Treat chronic pain Endpoint: Blood levels Status: NA Milestone: NA Data from an open-label study in 6 subjects showed that no quantifiable blood levels of naltrexone were observed at a limit of quantification LOQ ; of 7.5 pg ml. The study was designed to observe blood levels of naltrexone for 7 days following dosing under fed conditions. Indication: Treat chronic pain Endpoint: Blood levels Status: NA Milestone: NA Data from an open-label, U.S. study in 12 patients comparing naltrexone formulations showed that no quantifiable blood levels of naltrexone were released at a limit of quantification LOQ ; of 7.5 pg ml, when naltrexone was in its unaltered form. Data from the physically altered crushed formulation showed that significant amounts of naltrexone were released and absorbed with a Cmax of 3, 330 pg ml at the 30 minute time point. Erasmus University Medical Center, Rotterdam, the Netherlands Product: Pegylated interferon alpha Business: Infectious Molecular target: NA See next page.
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HIV-RNA status and the reasons for discontinuations of randomized treatment are summarized Table 14 ; . Table 14 Study ACTG 364 - Outcomes of Randomized Treatment Through 48 Weeks and loxitane.
Plasma Volume Expanders Low molecular weight dextran dextran 40 ; , when given intravenously, has a major effect of plasma volume expansion. Dextran 40 also enhances blood flow through correction of hypovolemia often present in freezing injury owing to marked peripheral vasoconstriction of the arterial capillary tree ; and improves microcirculation. It is considered to diminish or reverse erythrocyte aggregation. A good beginning dose may be 25 mL given by intravenous infusion or pump. Vasodilating Agents Tolazoline hydrochloride Priscoline hydrochloride * ; and isoxsuprine hydrochloride Vasdoilan ; presumably function by relaxing vascular smooth muscle. Priscoline is administered intravenously and Vasodiilan is administered orally. Generally the dose of Vaaodilan is 10 to mg, 3 or 4 times daily. Priscoline is also given subcutaneously at a dose of 10 to mg d, 4 times daily, beginning with low doses. Hemorheological Agents Pentoxifylline Trental * ; is said to increase vascular blood flow in patients with peripheral vascular disease by correcting pathologically altered platelet reactivity. It is administered orally or intravenously. The drug exhibits an inhibitory effect on platelet aggregation and on disseminated intravascular coagulation. Males usually are given oral doses of 400 mg three times daily. Hypotensive Agents Guanethidine monosulfate is said to produce a selective block of efferent peripheral sympathetic pathways, and is given orally, initially at a dose of 10 mg d. Reserpine, an ester alkaloid from certain Rauwolfia plant ; species that causes sympathetic inhibition resulting in vasodilation and increase cutaneous flow with flushing. It is given orally, 0.050.1 mg initially and then 0.1 mg every other day. Calcium ChannelBlocking Agents Nifedipine Procardia * ; presumably functions by inhibiting calcium ion influx. Nifedipine inhibits the contractile processes of cardiac and vascular smooth muscle, thereby dilating the main coronary and systemic arteries. It is given orally, 3060 mg once daily. Sympatholytic Agents Phenoxybenzamine hydrochloride Dibenzyline * ; blocks a-adrenergic receptors. The drug acts on vascular smooth muscle to block epinephrine-induced vasoconstriction and induces peripheral vasodilation. Dosage initially is 10 mg twice daily, increased to 20 mg twice daily after 2448 h. The hypotensive effects require increased intravenous or oral fluid intake. The drug is effective as a "medical sympathectomy." Dibenzyline and low molecular weight dextran are among the most effective postthaw drugs in the drug armamentarium. Anticoagulating Agents Heparin was used often in past decades, particularly for its antithrombotic effects. There is no substantial evidence of its effectiveness in freezing injury as compared with other drugs. Thrombolytic Enzymes Streptokinase, urokinase, and tissue plasminogen activator. Although great promise has been held out for all three enzymes, at present, patients with intracranial or intraspinal injury, or other trauma that would permit increase of local or systemic bleeding, cannot receive them. Using these drugs in patients whose cold injury has caused endothelial or capillary wall injury may cause further local bleeding and increased compartment pressure. Ongoing research13 involving these drugs in selected patients and centers may eventually determine an adequate, safe protocol for their use.
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ACT: Adjustable continence therapy: A minimally invasive post-operative adjustable therapy for female stress urinary incontinence. E. Kocjancic, T. Sauter, D. Minocci, G. Monesi, M. Favro, G. Ceratti, M. Sala, P. Gontero, S. Guglielmetti, S. Crivellaro, B. Frea Novara, Italy; Berlin, Germany ; Laparoscopic repair of recurrent prolapse H. Baumert, H. Widmer, R. Gupta, R. Adorna Rosa, B. Guilloneau, G. Vallencien Paris, France ; Innovational Video Prize Madrid 2003 Video-assisted nerve and prostate-sparing cystectomy X. Cathelineau Paris, France ; Research Video Prize Madrid 2003 Extraperitoneal laparoscopic radical prostatectomy C. Abbou, A. Hoznek, P. Antiphon, L. Salomon, A. De la Taille, R. Katz, D. Borkowski, D. Chopin Paris, France.
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